Hepatocyte-specific TM6SF2 knockout aggravates hepatic steatosis in mice with nonalcoholic fatty liver disease
ObjectiveTo establish a mouse model of hepatocyte-specific TM6SF2 knockout, and to investigate the role of TM6SF2 in the development of nonalcoholic fatty liver disease (NAFLD). MethodsThe CRISPR/Cas9 technique and the Cre/LoxP strategy were used to establish a stable mouse model of hepatocyte-speci...
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| Format: | article |
| Langue: | ZH |
| Publié: |
Editorial Department of Journal of Clinical Hepatology
2021
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| Accès en ligne: | https://doaj.org/article/4e7a05c4f9d44d5daeec0bea31f797ff |
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