Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate

Diadenosine polyphosphates (ApAs) are involved in cellular stress signaling but only a few molecular targets have been characterized so far. Here, the authors develop Ap n A-based photoaffinity-labeling probes and use them to identify Ap3A and Ap4A binding proteins in human cell lysates.

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Autores principales: Lena Krüger, Christoph J. Albrecht, Hannah K. Schammann, Florian M. Stumpf, Marie L. Niedermeier, Yizhi Yuan, Katrin Stuber, Josua Wimmer, Florian Stengel, Martin Scheffner, Andreas Marx
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4eb1898661044a6890c551d0a05b51d3
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