Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate

Diadenosine polyphosphates (ApAs) are involved in cellular stress signaling but only a few molecular targets have been characterized so far. Here, the authors develop Ap n A-based photoaffinity-labeling probes and use them to identify Ap3A and Ap4A binding proteins in human cell lysates.

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Autores principales:	Lena Krüger, Christoph J. Albrecht, Hannah K. Schammann, Florian M. Stumpf, Marie L. Niedermeier, Yizhi Yuan, Katrin Stuber, Josua Wimmer, Florian Stengel, Martin Scheffner, Andreas Marx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4eb1898661044a6890c551d0a05b51d3
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spelling	oai:doaj.org-article:4eb1898661044a6890c551d0a05b51d32021-12-02T16:56:43ZChemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate10.1038/s41467-021-26075-42041-1723https://doaj.org/article/4eb1898661044a6890c551d0a05b51d32021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26075-4https://doaj.org/toc/2041-1723Diadenosine polyphosphates (ApAs) are involved in cellular stress signaling but only a few molecular targets have been characterized so far. Here, the authors develop Ap n A-based photoaffinity-labeling probes and use them to identify Ap3A and Ap4A binding proteins in human cell lysates.Lena KrügerChristoph J. AlbrechtHannah K. SchammannFlorian M. StumpfMarie L. NiedermeierYizhi YuanKatrin StuberJosua WimmerFlorian StengelMartin ScheffnerAndreas MarxNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lena Krüger Christoph J. Albrecht Hannah K. Schammann Florian M. Stumpf Marie L. Niedermeier Yizhi Yuan Katrin Stuber Josua Wimmer Florian Stengel Martin Scheffner Andreas Marx Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
description	Diadenosine polyphosphates (ApAs) are involved in cellular stress signaling but only a few molecular targets have been characterized so far. Here, the authors develop Ap n A-based photoaffinity-labeling probes and use them to identify Ap3A and Ap4A binding proteins in human cell lysates.
format	article
author	Lena Krüger Christoph J. Albrecht Hannah K. Schammann Florian M. Stumpf Marie L. Niedermeier Yizhi Yuan Katrin Stuber Josua Wimmer Florian Stengel Martin Scheffner Andreas Marx
author_facet	Lena Krüger Christoph J. Albrecht Hannah K. Schammann Florian M. Stumpf Marie L. Niedermeier Yizhi Yuan Katrin Stuber Josua Wimmer Florian Stengel Martin Scheffner Andreas Marx
author_sort	Lena Krüger
title	Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
title_short	Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
title_full	Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
title_fullStr	Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
title_full_unstemmed	Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
title_sort	chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4eb1898661044a6890c551d0a05b51d3
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Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate

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