A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme

A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of antimetabolite drugs and is essential for vir...

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Autores principales: Inga R. Grin, Grigory V. Mechetin, Rustem D. Kasymov, Evgeniia A. Diatlova, Anna V. Yudkina, Sergei N. Shchelkunov, Irina P. Gileva, Alexandra A. Denisova, Grigoriy A. Stepanov, Ghermes G. Chilov, Dmitry O. Zharkov
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
DNA repair
uracil–DNA glycosylase
inhibitors
virtual screening
pyrimidines
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/4eccb9b2add64a62a6373d3ddfe88e90
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https://doaj.org/article/4eccb9b2add64a62a6373d3ddfe88e90

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