Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

Abstract A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Ph...

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Autores principales: Elnaz Yaghini, Ruggero Dondi, Kunal M. Tewari, Marilena Loizidou, Ian M. Eggleston, Alexander J. MacRobert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4f1101065e3c429892ad59ab68c9d579
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