A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Here Zhao et al. report a promising broad-spectrum antiviral alkaline peptide—P9R—that is active against several respiratory, pH-dependent viruses, including Influenza and SARS-CoV-2. P9R interferes with virus internalization by binding to the virus and subsequent inhibition of endosomal acidificati...

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Autores principales: Hanjun Zhao, Kelvin K. W. To, Kong-Hung Sze, Timothy Tin-Mong Yung, Mingjie Bian, Hoiyan Lam, Man Lung Yeung, Cun Li, Hin Chu, Kwok-Yung Yuen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4f2f6aa61091410cbf7c4f2708522cde
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Sumario:Here Zhao et al. report a promising broad-spectrum antiviral alkaline peptide—P9R—that is active against several respiratory, pH-dependent viruses, including Influenza and SARS-CoV-2. P9R interferes with virus internalization by binding to the virus and subsequent inhibition of endosomal acidification.