Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.

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Detalles Bibliográficos
Autores principales: Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
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https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4

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