Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.

Saved in:

Bibliographic Details
Main Authors:	Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:4f372d927b9744d19d8bbddc89834da4
record_format	dspace
spelling	oai:doaj.org-article:4f372d927b9744d19d8bbddc89834da42021-12-02T15:36:02ZTransposable element expression in tumors is associated with immune infiltration and increased antigenicity10.1038/s41467-019-13035-22041-1723https://doaj.org/article/4f372d927b9744d19d8bbddc89834da42019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13035-2https://doaj.org/toc/2041-1723Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.Yu KongChristopher M. RoseAshley A. CassAlexander G. WilliamsMartine DarwishSteve LianoglouPeter M. HavertyAnn-Jay TongCraig BlanchetteMatthew L. AlbertIra MellmanRichard BourgonJohn GreallySuchit JhunjhunwalaHaiyin Chen-HarrisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Kong Christopher M. Rose Ashley A. Cass Alexander G. Williams Martine Darwish Steve Lianoglou Peter M. Haverty Ann-Jay Tong Craig Blanchette Matthew L. Albert Ira Mellman Richard Bourgon John Greally Suchit Jhunjhunwala Haiyin Chen-Harris Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
description	Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
format	article
author	Yu Kong Christopher M. Rose Ashley A. Cass Alexander G. Williams Martine Darwish Steve Lianoglou Peter M. Haverty Ann-Jay Tong Craig Blanchette Matthew L. Albert Ira Mellman Richard Bourgon John Greally Suchit Jhunjhunwala Haiyin Chen-Harris
author_facet	Yu Kong Christopher M. Rose Ashley A. Cass Alexander G. Williams Martine Darwish Steve Lianoglou Peter M. Haverty Ann-Jay Tong Craig Blanchette Matthew L. Albert Ira Mellman Richard Bourgon John Greally Suchit Jhunjhunwala Haiyin Chen-Harris
author_sort	Yu Kong
title	Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
title_short	Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
title_full	Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
title_fullStr	Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
title_full_unstemmed	Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
title_sort	transposable element expression in tumors is associated with immune infiltration and increased antigenicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
work_keys_str_mv	AT yukong transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT christophermrose transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT ashleyacass transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT alexandergwilliams transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT martinedarwish transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT stevelianoglou transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT petermhaverty transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT annjaytong transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT craigblanchette transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT matthewlalbert transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT iramellman transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT richardbourgon transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT johngreally transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT suchitjhunjhunwala transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity AT haiyinchenharris transposableelementexpressionintumorsisassociatedwithimmuneinfiltrationandincreasedantigenicity
_version_	1718386351812902912

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Similar Items