Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.

Saved in:
Bibliographic Details
Main Authors: Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4

Similar Items