CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

Louise van der Weyden et al. report a CRISPRa screen in mice to identify membrane protein-encoding genes that, when overexpressed, enhance the metastatic potential of melanoma cells. They find that high expression of LRRN4CL in melanoma cells increases lung metastases in mice and correlates with poo...

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Autores principales:	Louise van der Weyden, Victoria Harle, Gemma Turner, Victoria Offord, Vivek Iyer, Alastair Droop, Agnieszka Swiatkowska, Roy Rabbie, Andrew D. Campbell, Owen J. Sansom, Mercedes Pardo, Jyoti S. Choudhary, Ingrid Ferreira, Mark Tullett, Mark J. Arends, Anneliese O. Speak, David J. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4f4c4eec5cbe46db9a452ba009fd123d
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spelling	oai:doaj.org-article:4f4c4eec5cbe46db9a452ba009fd123d2021-12-02T16:36:02ZCRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation10.1038/s42003-021-01912-w2399-3642https://doaj.org/article/4f4c4eec5cbe46db9a452ba009fd123d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01912-whttps://doaj.org/toc/2399-3642Louise van der Weyden et al. report a CRISPRa screen in mice to identify membrane protein-encoding genes that, when overexpressed, enhance the metastatic potential of melanoma cells. They find that high expression of LRRN4CL in melanoma cells increases lung metastases in mice and correlates with poorer survival in melanoma patients, suggesting it could be a promising drug target.Louise van der WeydenVictoria HarleGemma TurnerVictoria OffordVivek IyerAlastair DroopAgnieszka SwiatkowskaRoy RabbieAndrew D. CampbellOwen J. SansomMercedes PardoJyoti S. ChoudharyIngrid FerreiraMark TullettMark J. ArendsAnneliese O. SpeakDavid J. AdamsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Louise van der Weyden Victoria Harle Gemma Turner Victoria Offord Vivek Iyer Alastair Droop Agnieszka Swiatkowska Roy Rabbie Andrew D. Campbell Owen J. Sansom Mercedes Pardo Jyoti S. Choudhary Ingrid Ferreira Mark Tullett Mark J. Arends Anneliese O. Speak David J. Adams CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
description	Louise van der Weyden et al. report a CRISPRa screen in mice to identify membrane protein-encoding genes that, when overexpressed, enhance the metastatic potential of melanoma cells. They find that high expression of LRRN4CL in melanoma cells increases lung metastases in mice and correlates with poorer survival in melanoma patients, suggesting it could be a promising drug target.
format	article
author	Louise van der Weyden Victoria Harle Gemma Turner Victoria Offord Vivek Iyer Alastair Droop Agnieszka Swiatkowska Roy Rabbie Andrew D. Campbell Owen J. Sansom Mercedes Pardo Jyoti S. Choudhary Ingrid Ferreira Mark Tullett Mark J. Arends Anneliese O. Speak David J. Adams
author_facet	Louise van der Weyden Victoria Harle Gemma Turner Victoria Offord Vivek Iyer Alastair Droop Agnieszka Swiatkowska Roy Rabbie Andrew D. Campbell Owen J. Sansom Mercedes Pardo Jyoti S. Choudhary Ingrid Ferreira Mark Tullett Mark J. Arends Anneliese O. Speak David J. Adams
author_sort	Louise van der Weyden
title	CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
title_short	CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
title_full	CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
title_fullStr	CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
title_full_unstemmed	CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
title_sort	crispr activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f4c4eec5cbe46db9a452ba009fd123d
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CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

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