Molecular switching system using glycosylphosphatidylinositol to select cells highly expressing recombinant proteins

Abstract Although many pharmaceutical proteins are produced in mammalian cells, there remains a challenge to select cell lines that express recombinant proteins with high productivity. Since most biopharmaceutical proteins are secreted by cells into the medium, it is difficult to select cell lines t...

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Autores principales: Emmanuel Matabaro, Zeng’an He, Yi-Shi Liu, Hui-Jie Zhang, Xiao-Dong Gao, Morihisa Fujita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4f584acd06094ce5b04b57b53a29be8f
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