Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2

Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2

<b>Background:</b> Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors, in addition to the antiretroviral properties, possess pleiotropic pharmacological effects including anticancer action. Therefore, we investigated the pro-apoptotic activity in tumor cells...

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Autores principales: Roberta Rinaldi, Rocchina Miglionico, Ilaria Nigro, Rosarita D’Orsi, Lucia Chiummiento, Maria Funicello, Paolo Lupattelli, Ilaria Laurenzana, Alessandro Sgambato, Magnus Monné, Faustino Bisaccia, Maria Francesca Armentano
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
HIV-1 protease inhibitors
apoptosis
ER stress
UPR
proteasome
autophagy
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/4f869766409b445eb03c8b269d245fe7
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https://doaj.org/article/4f869766409b445eb03c8b269d245fe7

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