Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2
<b>Background:</b> Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors, in addition to the antiretroviral properties, possess pleiotropic pharmacological effects including anticancer action. Therefore, we investigated the pro-apoptotic activity in tumor cells...
Guardado en:
Autores principales: | Roberta Rinaldi, Rocchina Miglionico, Ilaria Nigro, Rosarita D’Orsi, Lucia Chiummiento, Maria Funicello, Paolo Lupattelli, Ilaria Laurenzana, Alessandro Sgambato, Magnus Monné, Faustino Bisaccia, Maria Francesca Armentano |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4f869766409b445eb03c8b269d245fe7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
por: Morvarid Siri, et al.
Publicado: (2020) -
The Pseudo-Symmetric <i>N</i>-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation
por: Rosarita D’Orsi, et al.
Publicado: (2021) -
A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes
por: Alexander Burov, et al.
Publicado: (2021) -
<named-content content-type="genus-species">Toxoplasma gondii</named-content> Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells
por: Leonardo Augusto, et al.
Publicado: (2020) -
On the Role of the Immunoproteasome in Protein Homeostasis
por: Michael Basler, et al.
Publicado: (2021)