Cinacalcet Targets the Neurokinin-1 Receptor and Inhibits PKCδ/ERK/P65 Signaling to Alleviate Dextran Sulfate Sodium-Induced Colitis

QR Code

Cinacalcet Targets the Neurokinin-1 Receptor and Inhibits PKCδ/ERK/P65 Signaling to Alleviate Dextran Sulfate Sodium-Induced Colitis

Objective: Inflammatory bowel disease is an immune-mediated chronic inflammatory disease of the gastrointestinal tract for which curative drugs are currently not available. This study was performed to assess the therapeutic effects of cinacalcet on dextran sulfate sodium (DSS)-induced colitis.Method...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yuehong Chen, Huan Liu, Qiuping Zhang, Yubin Luo, Liang Wu, Yutong Zhong, Zhigang Tang, Yaoyu Pu, Chenyang Lu, Geng Yin, Qibing Xie
Format:	article
Language:	EN
Published:	Frontiers Media S.A. 2021
Subjects:	cinacalcet inflammatory bowel disease neurokinin-1 receptor tumor necrosis factor α NF-κB Therapeutics. Pharmacology RM1-950
Online Access:	https://doaj.org/article/4f9a4e7768d74152aecc4523183a077c
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A single-centre retrospective analysis of cinacalcet therapy in primary hyperparathyroidism
by: Daniel Bell, et al.
Published: (2021)

Severe Symptomatic Hypocalcemia, complicating cardiac arrhythmia following Cinacalcet (SensiparTM) administration: A Case Report
by: Gregory S. Schmidt, et al.
Published: (2021)

Substance P/ Neurokinin-1 Receptor, Trigeminal Ganglion, Latency, and Coronavirus Infection-Is There Any Link?
by: Riffat Mehboob, et al.
Published: (2021)

Comparison between paricalcitol versus cinacalcet therapy in the management of secondary hyperparathyroidism among prevalent hemodialysis patients
by: Maha A. Behairy, et al.
Published: (2022)

Lactobacillus fermentum ZS40 Ameliorates Inflammation in Mice With Ulcerative Colitis Induced by Dextran Sulfate Sodium
by: Zixia Chen, et al.
Published: (2021)

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
by: Giridharan S, et al.
Published: (2018)

A comparative study on the effect of calcitriol and cinacalcet on hyperparathyroidism in hemodialysis patients; a double-blinded randomized clinical trial
by: Saeed Mardani, et al.
Published: (2022)

Effect of Huoxue Huayu Lishui Decoction on P65 and TAK1 of acute soft tissue injury in rats
by: Kang Wang, et al.
Published: (2021)

Stilbene glycoside protects osteoblasts against oxidative damage via Nrf2/HO-1 and NF-κB signaling pathways
by: Jian Cheng, et al.
Published: (2018)

Dimethyl Fumarate Targets MSK1, RSK1, 2 and IKKα/β Kinases and Regulates NF-κB /p65 Activation in Psoriasis: A Demonstration of the Effect on Peripheral Blood Mononuclear Cells, Drawn from Two Patients with Severe Psoriasis Before and After Treatment with Dimethyl Fumarate
by: Gesser B, et al.
Published: (2020)

VSTM1 regulates monocyte/macrophage function via the NF-κB signaling pathway
by: Wang Xiao-Fei, et al.
Published: (2021)

Functional Multigenomic Screening of Human-Associated Bacteria for NF-κB-Inducing Bioactive Effectors
by: Andreia B. Estrela, et al.
Published: (2019)

Enhanced Chemotherapeutic Efficacy of PLGA-Encapsulated Epigallocatechin Gallate (EGCG) Against Human Lung Cancer
by: Zhang L, et al.
Published: (2020)

Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways
by: Noha F. Abdelkader, et al.
Published: (2022)

Chitosan-Poly(Acrylic Acid) Nanoparticles Loaded with R848 and MnCl2 Inhibit Melanoma via Regulating Macrophage Polarization and Dendritic Cell Maturation
by: Liu X, et al.
Published: (2021)

New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
by: Tu Rong-Hui, et al.
Published: (2021)

The analgesic and anti-inflammatory effects of zukamu granules, a traditional Chinese medical formulation
by: Qiang Yin, et al.
Published: (2019)

Inhibitory Effect of Punicalagin on Inflammatory and Angiogenic Activation of Human Umbilical Vein Endothelial Cells
by: Wei Liu, et al.
Published: (2021)

Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation
by: Xue-Fei Wu, et al.
Published: (2021)

Corrigendum: Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation
by: Xue-Fei Wu, et al.
Published: (2021)

miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway
by: Zhou Weidong, et al.
Published: (2021)

Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts
by: Tao Li, et al.
Published: (2021)

Endogenous ornithine decarboxylase/polyamine system mediated the antagonist role of insulin/PEG-CMCS preconditioning against heart ischemia/reperfusion injury in diabetes mellitus
by: Tong F, et al.
Published: (2018)

Isoorientin Inhibits Amyloid β<sub>25–35</sub>-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
by: Buyun Kim, et al.
Published: (2021)

Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis
by: Shenghua Yu, et al.
Published: (2021)

New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
by: Andrew D. Yurochko
Published: (2017)

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases
by: Weijun Wu, et al.
Published: (2021)

Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity
by: Huang JM, et al.
Published: (2021)

Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism
by: Venugopal Gunda, et al.
Published: (2021)

Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
by: Qiu-Cheng Li, et al.
Published: (2021)

CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway
by: Gong Y, et al.
Published: (2017)

MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer
by: Changwen Li, et al.
Published: (2021)

The Supportive Role of NSC328382, a P2X7R Antagonist, in Enhancing the Inhibitory Effect of CRID3 on NLRP3 Inflammasome Activation in Rats with Dextran Sodium Sulfate-Induced Colitis
by: Saber S, et al.
Published: (2021)

Spotlight on the perioperative use of maropitant citrate
by: Hay Kraus BL
Published: (2017)

Immunostimulatory properties of heat-resistant RNA in a decoction of Glycyrrhizae Radix
by: Akiko Inujima, et al.
Published: (2022)

Knockdown of circ_0003204 alleviates oxidative low-density lipoprotein-induced human umbilical vein endothelial cells injury: Circulating RNAs could explain atherosclerosis disease progression
by: Su Qiuxia, et al.
Published: (2021)

Long noncoding RNA MIAT inhibits the progression of diabetic nephropathy and the activation of NF-κB pathway in high glucose-treated renal tubular epithelial cells by the miR-182-5p/GPRC5A axis
by: Dong Qianlan, et al.
Published: (2021)

The Role of microRNA-15A in the Development of Prostate Cancer – Effects on Cell Proliferation and Pro-Inflammatory Signalling
by: Apostolova A., et al.
Published: (2018)

Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
by: Zhu-Xia Tan, et al.
Published: (2021)

Protective effect of Lactobacillus-containing probiotics on intestinal mucosa of rats experiencing traumatic hemorrhagic shock
by: Wang Lei, et al.
Published: (2021)