Cinacalcet Targets the Neurokinin-1 Receptor and Inhibits PKCδ/ERK/P65 Signaling to Alleviate Dextran Sulfate Sodium-Induced Colitis

Cinacalcet Targets the Neurokinin-1 Receptor and Inhibits PKCδ/ERK/P65 Signaling to Alleviate Dextran Sulfate Sodium-Induced Colitis

Objective: Inflammatory bowel disease is an immune-mediated chronic inflammatory disease of the gastrointestinal tract for which curative drugs are currently not available. This study was performed to assess the therapeutic effects of cinacalcet on dextran sulfate sodium (DSS)-induced colitis.Method...

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Bibliographic Details
Main Authors: Yuehong Chen, Huan Liu, Qiuping Zhang, Yubin Luo, Liang Wu, Yutong Zhong, Zhigang Tang, Yaoyu Pu, Chenyang Lu, Geng Yin, Qibing Xie
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
cinacalcet
inflammatory bowel disease
neurokinin-1 receptor
tumor necrosis factor α
NF-κB
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/4f9a4e7768d74152aecc4523183a077c
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https://doaj.org/article/4f9a4e7768d74152aecc4523183a077c

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