Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

ABSTRACT The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protect...

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Auteurs principaux: Jin Gao, Laura Couzens, David F. Burke, Hongquan Wan, Patrick Wilson, Matthew J. Memoli, Xiyan Xu, Ruth Harvey, Jens Wrammert, Rafi Ahmed, Jeffery K. Taubenberger, Derek J. Smith, Ron A. M. Fouchier, Maryna C. Eichelberger
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
Sujets:
antigenic drift
influenza
monoclonal antibodies
neuraminidase
vaccines
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/4fb13969619245be873ed38e9f58971b
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https://doaj.org/article/4fb13969619245be873ed38e9f58971b

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