Deep generative neural network for accurate drug response imputation

Drug response in cancer patients vary dramatically due to inter- and intra-tumor heterogeneity and transcriptome context plays a significant role in shaping the actual treatment outcome. Here, the authors develop a deep variational autoencoder model to compress gene signatures into latent vectors an...

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Autores principales: Peilin Jia, Ruifeng Hu, Guangsheng Pei, Yulin Dai, Yin-Ying Wang, Zhongming Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4fb77b5018df4b45a1a0baa6a40058e4
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