Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.

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Bibliographic Details
Main Authors:	Krista Dubin, Margaret K. Callahan, Boyu Ren, Raya Khanin, Agnes Viale, Lilan Ling, Daniel No, Asia Gobourne, Eric Littmann, Curtis Huttenhower, Eric G. Pamer, Jedd D. Wolchok
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e
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spelling	oai:doaj.org-article:4fd307aaea2d42b5882a076b1df4053e2021-12-02T14:38:34ZIntestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis10.1038/ncomms103912041-1723https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10391https://doaj.org/toc/2041-1723A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.Krista DubinMargaret K. CallahanBoyu RenRaya KhaninAgnes VialeLilan LingDaniel NoAsia GobourneEric LittmannCurtis HuttenhowerEric G. PamerJedd D. WolchokNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
description	A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.
format	article
author	Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok
author_facet	Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok
author_sort	Krista Dubin
title	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_short	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_full	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_fullStr	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_full_unstemmed	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_sort	intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e
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Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

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