Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Krista Dubin, Margaret K. Callahan, Boyu Ren, Raya Khanin, Agnes Viale, Lilan Ling, Daniel No, Asia Gobourne, Eric Littmann, Curtis Huttenhower, Eric G. Pamer, Jedd D. Wolchok
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:4fd307aaea2d42b5882a076b1df4053e
record_format	dspace
spelling	oai:doaj.org-article:4fd307aaea2d42b5882a076b1df4053e2021-12-02T14:38:34ZIntestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis10.1038/ncomms103912041-1723https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10391https://doaj.org/toc/2041-1723A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.Krista DubinMargaret K. CallahanBoyu RenRaya KhaninAgnes VialeLilan LingDaniel NoAsia GobourneEric LittmannCurtis HuttenhowerEric G. PamerJedd D. WolchokNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
description	A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.
format	article
author	Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok
author_facet	Krista Dubin Margaret K. Callahan Boyu Ren Raya Khanin Agnes Viale Lilan Ling Daniel No Asia Gobourne Eric Littmann Curtis Huttenhower Eric G. Pamer Jedd D. Wolchok
author_sort	Krista Dubin
title	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_short	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_full	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_fullStr	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_full_unstemmed	Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
title_sort	intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4fd307aaea2d42b5882a076b1df4053e
work_keys_str_mv	AT kristadubin intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT margaretkcallahan intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT boyuren intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT rayakhanin intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT agnesviale intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT lilanling intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT danielno intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT asiagobourne intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT ericlittmann intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT curtishuttenhower intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT ericgpamer intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis AT jedddwolchok intestinalmicrobiomeanalysesidentifymelanomapatientsatriskforcheckpointblockadeinducedcolitis
_version_	1718390949647745024

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

Documents similaires