Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.

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Autores principales:	Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4fd74a8582194eebb54003eaafc6eecf
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spelling	oai:doaj.org-article:4fd74a8582194eebb54003eaafc6eecf2021-12-02T16:24:57ZNeonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk10.1038/s41467-020-17477-x2041-1723https://doaj.org/article/4fd74a8582194eebb54003eaafc6eecf2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17477-xhttps://doaj.org/toc/2041-1723Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.Qin Qin HuangHoward H. F. TangShu Mei TeoDanny MokScott C. RitchieArtika P. NathMarta BrozynskaAgus SalimAndrew BakshiBarbara J. HoltChiea Chuen KhorPeter D. SlyPatrick G. HoltKathryn E. HoltMichael InouyeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Qin Huang Howard H. F. Tang Shu Mei Teo Danny Mok Scott C. Ritchie Artika P. Nath Marta Brozynska Agus Salim Andrew Bakshi Barbara J. Holt Chiea Chuen Khor Peter D. Sly Patrick G. Holt Kathryn E. Holt Michael Inouye Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
description	Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.
format	article
author	Qin Qin Huang Howard H. F. Tang Shu Mei Teo Danny Mok Scott C. Ritchie Artika P. Nath Marta Brozynska Agus Salim Andrew Bakshi Barbara J. Holt Chiea Chuen Khor Peter D. Sly Patrick G. Holt Kathryn E. Holt Michael Inouye
author_facet	Qin Qin Huang Howard H. F. Tang Shu Mei Teo Danny Mok Scott C. Ritchie Artika P. Nath Marta Brozynska Agus Salim Andrew Bakshi Barbara J. Holt Chiea Chuen Khor Peter D. Sly Patrick G. Holt Kathryn E. Holt Michael Inouye
author_sort	Qin Qin Huang
title	Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
title_short	Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
title_full	Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
title_fullStr	Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
title_full_unstemmed	Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
title_sort	neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4fd74a8582194eebb54003eaafc6eecf
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Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

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