Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.

Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 signaling. Tbx1 interferes with Smad1 to Smad4 bindin...

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Autores principales: F Gabriella Fulcoli, Tuong Huynh, Peter J Scambler, Antonio Baldini
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/4fd81bfa1a8b48f2a564b7a9aade4f0a
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