Single-molecule theory of enzymatic inhibition

Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.

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Bibliographic Details
Main Authors: Tal Robin, Shlomi Reuveni, Michael Urbakh
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/4ff682a5b6ec47f9b1d180b0cef1fdf2
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