Bone morphogenetic protein 7 promotes resistance to immunotherapy

Bone morphogenetic protein 7 promotes resistance to immunotherapy

The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.

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Autores principales: Maria Angelica Cortez, Fatemeh Masrorpour, Cristina Ivan, Jie Zhang, Ahmed I. Younes, Yue Lu, Marcos R Estecio, Hampartsoum B. Barsoumian, Hari Menon, Mauricio da Silva Caetano, Rishab Ramapriyan, Jonathan E. Schoenhals, Xiaohong Wang, Ferdinandos Skoulidis, Mark D. Wasley, George Calin, Patrick Hwu, James W. Welsh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/50194472a306497690c2c253af5c1808
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https://doaj.org/article/50194472a306497690c2c253af5c1808

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