Bone morphogenetic protein 7 promotes resistance to immunotherapy

The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.

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Autores principales:	Maria Angelica Cortez, Fatemeh Masrorpour, Cristina Ivan, Jie Zhang, Ahmed I. Younes, Yue Lu, Marcos R Estecio, Hampartsoum B. Barsoumian, Hari Menon, Mauricio da Silva Caetano, Rishab Ramapriyan, Jonathan E. Schoenhals, Xiaohong Wang, Ferdinandos Skoulidis, Mark D. Wasley, George Calin, Patrick Hwu, James W. Welsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50194472a306497690c2c253af5c1808
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spelling	oai:doaj.org-article:50194472a306497690c2c253af5c18082021-12-02T18:48:04ZBone morphogenetic protein 7 promotes resistance to immunotherapy10.1038/s41467-020-18617-z2041-1723https://doaj.org/article/50194472a306497690c2c253af5c18082020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18617-zhttps://doaj.org/toc/2041-1723The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.Maria Angelica CortezFatemeh MasrorpourCristina IvanJie ZhangAhmed I. YounesYue LuMarcos R EstecioHampartsoum B. BarsoumianHari MenonMauricio da Silva CaetanoRishab RamapriyanJonathan E. SchoenhalsXiaohong WangFerdinandos SkoulidisMark D. WasleyGeorge CalinPatrick HwuJames W. WelshNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh Bone morphogenetic protein 7 promotes resistance to immunotherapy
description	The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.
format	article
author	Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh
author_facet	Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh
author_sort	Maria Angelica Cortez
title	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_short	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_full	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_fullStr	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_full_unstemmed	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_sort	bone morphogenetic protein 7 promotes resistance to immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/50194472a306497690c2c253af5c1808
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Bone morphogenetic protein 7 promotes resistance to immunotherapy

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