Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability

The interplay between driver mutations and aneuploidy during tumorigenesis is largely unexplored. Here, the authors show two types of associations, leading to different therapeutic vulnerabilities and prognoses.

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Detalles Bibliográficos
Autores principales:	Noam Auslander, Yuri I. Wolf, Eugene V. Koonin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/508a4ed569754b8f9b56fc8d430a3718
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spelling	oai:doaj.org-article:508a4ed569754b8f9b56fc8d430a37182021-12-02T14:40:27ZInterplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability10.1038/s41467-020-15094-22041-1723https://doaj.org/article/508a4ed569754b8f9b56fc8d430a37182020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15094-2https://doaj.org/toc/2041-1723The interplay between driver mutations and aneuploidy during tumorigenesis is largely unexplored. Here, the authors show two types of associations, leading to different therapeutic vulnerabilities and prognoses.Noam AuslanderYuri I. WolfEugene V. KooninNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noam Auslander Yuri I. Wolf Eugene V. Koonin Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
description	The interplay between driver mutations and aneuploidy during tumorigenesis is largely unexplored. Here, the authors show two types of associations, leading to different therapeutic vulnerabilities and prognoses.
format	article
author	Noam Auslander Yuri I. Wolf Eugene V. Koonin
author_facet	Noam Auslander Yuri I. Wolf Eugene V. Koonin
author_sort	Noam Auslander
title	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
title_short	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
title_full	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
title_fullStr	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
title_full_unstemmed	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
title_sort	interplay between dna damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/508a4ed569754b8f9b56fc8d430a3718
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Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability

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