Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
The interplay between driver mutations and aneuploidy during tumorigenesis is largely unexplored. Here, the authors show two types of associations, leading to different therapeutic vulnerabilities and prognoses.
Guardado en:
Autores principales: | Noam Auslander, Yuri I. Wolf, Eugene V. Koonin |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/508a4ed569754b8f9b56fc8d430a3718 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Chromosome arm aneuploidies shape tumour evolution and drug response
por: Ankit Shukla, et al.
Publicado: (2020) -
Molecular signatures of aneuploidy-driven adaptive evolution
por: Alaattin Kaya, et al.
Publicado: (2020) -
Mutational signatures are jointly shaped by DNA damage and repair
por: Nadezda V. Volkova, et al.
Publicado: (2020) -
Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes
por: Tatiana G. Senkevich, et al.
Publicado: (2021) -
Prognostic impact of microsatellite instability in gastric cancer
por: Cesar Zepeda-Najar, et al.
Publicado: (2021)