C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

Abstract Subjects carrying the C2238 variant of the atrial natriuretic peptide (ANP) gene have a higher occurrence of stroke and acute coronary syndrome, suggesting an increased predisposition to acute thrombotic events in these subjects. We evaluated for the first time the direct effects of mutant...

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Autores principales: Roberto Carnevale, Pasquale Pignatelli, Giacomo Frati, Cristina Nocella, Rosita Stanzione, Daniele Pastori, Simona Marchitti, Valentina Valenti, Maria Santulli, Emanuele Barbato, Teresa Strisciuglio, Leonardo Schirone, Carmine Vecchione, Francesco Violi, Massimo Volpe, Speranza Rubattu, Sebastiano Sciarretta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/5096f14f92b54f8a9f71e3827294a48d
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https://doaj.org/article/5096f14f92b54f8a9f71e3827294a48d

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