Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

Guardado en:
Detalles Bibliográficos
Autores principales: Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney, William M. Shih
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/50a682a815284a8485d185a430fa9b97
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/50a682a815284a8485d185a430fa9b97

Ejemplares similares