Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

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Autores principales:	Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney, William M. Shih
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50a682a815284a8485d185a430fa9b97
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spelling	oai:doaj.org-article:50a682a815284a8485d185a430fa9b972021-12-02T14:40:33ZOligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation10.1038/ncomms156542041-1723https://doaj.org/article/50a682a815284a8485d185a430fa9b972017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15654https://doaj.org/toc/2041-1723The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.Nandhini PonnuswamyMaartje M. C. BastingsBhavik NathwaniJu Hee RyuLeo Y. T. ChouMathias VintherWeiwei Aileen LiFrances M. AnastassacosDavid J. MooneyWilliam M. ShihNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nandhini Ponnuswamy Maartje M. C. Bastings Bhavik Nathwani Ju Hee Ryu Leo Y. T. Chou Mathias Vinther Weiwei Aileen Li Frances M. Anastassacos David J. Mooney William M. Shih Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
description	The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.
format	article
author	Nandhini Ponnuswamy Maartje M. C. Bastings Bhavik Nathwani Ju Hee Ryu Leo Y. T. Chou Mathias Vinther Weiwei Aileen Li Frances M. Anastassacos David J. Mooney William M. Shih
author_facet	Nandhini Ponnuswamy Maartje M. C. Bastings Bhavik Nathwani Ju Hee Ryu Leo Y. T. Chou Mathias Vinther Weiwei Aileen Li Frances M. Anastassacos David J. Mooney William M. Shih
author_sort	Nandhini Ponnuswamy
title	Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
title_short	Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
title_full	Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
title_fullStr	Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
title_full_unstemmed	Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
title_sort	oligolysine-based coating protects dna nanostructures from low-salt denaturation and nuclease degradation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50a682a815284a8485d185a430fa9b97
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Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

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