Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

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Detalles Bibliográficos
Autores principales: Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney, William M. Shih
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/50a682a815284a8485d185a430fa9b97
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