Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification
Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification.
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Nature Portfolio
2016
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oai:doaj.org-article:50a7efdd53054d58bdc66c48775ef3ba2021-12-02T15:34:52ZMitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification10.1038/ncomms117102041-1723https://doaj.org/article/50a7efdd53054d58bdc66c48775ef3ba2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11710https://doaj.org/toc/2041-1723Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification.Wim DejongheSabine KuenenEvelien MylleMina VasilevaOlivier KeechCorrado ViottiJef SwertsMatyáš FendrychFausto Andres Ortiz-MoreaKiril MishevSimon DelangStefan SchollXavier ZarzaMareike HeilmannJiorgos KourelisJaroslaw KasprowiczLe Son Long NguyenAndrzej DrozdzeckiIsabelle Van HoutteAnna-Mária SzatmáriMateusz MajdaGary BaisaSebastian York BednarekStéphanie RobertDominique AudenaertChrista TesterinkTeun MunnikDaniël Van DammeIngo HeilmannKarin SchumacherJohan WinneJiří FrimlPatrik VerstrekenEugenia RussinovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Science Q Wim Dejonghe Sabine Kuenen Evelien Mylle Mina Vasileva Olivier Keech Corrado Viotti Jef Swerts Matyáš Fendrych Fausto Andres Ortiz-Morea Kiril Mishev Simon Delang Stefan Scholl Xavier Zarza Mareike Heilmann Jiorgos Kourelis Jaroslaw Kasprowicz Le Son Long Nguyen Andrzej Drozdzecki Isabelle Van Houtte Anna-Mária Szatmári Mateusz Majda Gary Baisa Sebastian York Bednarek Stéphanie Robert Dominique Audenaert Christa Testerink Teun Munnik Daniël Van Damme Ingo Heilmann Karin Schumacher Johan Winne Jiří Friml Patrik Verstreken Eugenia Russinova Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| description |
Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification. |
| format |
article |
| author |
Wim Dejonghe Sabine Kuenen Evelien Mylle Mina Vasileva Olivier Keech Corrado Viotti Jef Swerts Matyáš Fendrych Fausto Andres Ortiz-Morea Kiril Mishev Simon Delang Stefan Scholl Xavier Zarza Mareike Heilmann Jiorgos Kourelis Jaroslaw Kasprowicz Le Son Long Nguyen Andrzej Drozdzecki Isabelle Van Houtte Anna-Mária Szatmári Mateusz Majda Gary Baisa Sebastian York Bednarek Stéphanie Robert Dominique Audenaert Christa Testerink Teun Munnik Daniël Van Damme Ingo Heilmann Karin Schumacher Johan Winne Jiří Friml Patrik Verstreken Eugenia Russinova |
| author_facet |
Wim Dejonghe Sabine Kuenen Evelien Mylle Mina Vasileva Olivier Keech Corrado Viotti Jef Swerts Matyáš Fendrych Fausto Andres Ortiz-Morea Kiril Mishev Simon Delang Stefan Scholl Xavier Zarza Mareike Heilmann Jiorgos Kourelis Jaroslaw Kasprowicz Le Son Long Nguyen Andrzej Drozdzecki Isabelle Van Houtte Anna-Mária Szatmári Mateusz Majda Gary Baisa Sebastian York Bednarek Stéphanie Robert Dominique Audenaert Christa Testerink Teun Munnik Daniël Van Damme Ingo Heilmann Karin Schumacher Johan Winne Jiří Friml Patrik Verstreken Eugenia Russinova |
| author_sort |
Wim Dejonghe |
| title |
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| title_short |
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| title_full |
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| title_fullStr |
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| title_full_unstemmed |
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| title_sort |
mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/50a7efdd53054d58bdc66c48775ef3ba |
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