Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

The use of CSF for diagnosis of metastatic brain tumors could be of clinical and patient benefit. Here the authors undertake a single-cell RNA analysis of CSF and brain to determine whether the phenotype in the CSF is reflective of the phenotype in the tumor.

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Bibliographic Details
Main Authors: Carlota Rubio-Perez, Ester Planas-Rigol, Juan L. Trincado, Ester Bonfill-Teixidor, Alexandra Arias, Domenica Marchese, Catia Moutinho, Garazi Serna, Leire Pedrosa, Raffaella Iurlaro, Francisco Martínez-Ricarte, Laura Escudero, Esteban Cordero, Marta Cicuendez, Sara Ruiz, Genís Parra, Paolo Nuciforo, Josep Gonzalez, Estela Pineda, Juan Sahuquillo, Josep Tabernero, Holger Heyn, Joan Seoane
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/50b186a5ef3f4b8e915baf48cb69dbc4
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Summary:The use of CSF for diagnosis of metastatic brain tumors could be of clinical and patient benefit. Here the authors undertake a single-cell RNA analysis of CSF and brain to determine whether the phenotype in the CSF is reflective of the phenotype in the tumor.

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