Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression.
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Nature Portfolio
2020
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oai:doaj.org-article:50c3ca33473a428aa36c9a52cf6638ef2021-12-02T13:57:45ZGlioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype10.1038/s41467-020-20225-w2041-1723https://doaj.org/article/50c3ca33473a428aa36c9a52cf6638ef2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20225-whttps://doaj.org/toc/2041-1723Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression.Yonghe WuMichael FletcherZuguang GuQi WangBarbara CostaAnna BertoniKa-Hou ManMagdalena SchlotterJörg FelsbergJasmin MangeiMartje BarbusAnn-Christin GaupelWei WangTobias WeissRoland EilsMichael WellerHaikun LiuGuido ReifenbergerAndrey KorshunovPeter AngelPeter LichterCarl HerrmannBernhard RadlwimmerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yonghe Wu Michael Fletcher Zuguang Gu Qi Wang Barbara Costa Anna Bertoni Ka-Hou Man Magdalena Schlotter Jörg Felsberg Jasmin Mangei Martje Barbus Ann-Christin Gaupel Wei Wang Tobias Weiss Roland Eils Michael Weller Haikun Liu Guido Reifenberger Andrey Korshunov Peter Angel Peter Lichter Carl Herrmann Bernhard Radlwimmer Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| description |
Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression. |
| format |
article |
| author |
Yonghe Wu Michael Fletcher Zuguang Gu Qi Wang Barbara Costa Anna Bertoni Ka-Hou Man Magdalena Schlotter Jörg Felsberg Jasmin Mangei Martje Barbus Ann-Christin Gaupel Wei Wang Tobias Weiss Roland Eils Michael Weller Haikun Liu Guido Reifenberger Andrey Korshunov Peter Angel Peter Lichter Carl Herrmann Bernhard Radlwimmer |
| author_facet |
Yonghe Wu Michael Fletcher Zuguang Gu Qi Wang Barbara Costa Anna Bertoni Ka-Hou Man Magdalena Schlotter Jörg Felsberg Jasmin Mangei Martje Barbus Ann-Christin Gaupel Wei Wang Tobias Weiss Roland Eils Michael Weller Haikun Liu Guido Reifenberger Andrey Korshunov Peter Angel Peter Lichter Carl Herrmann Bernhard Radlwimmer |
| author_sort |
Yonghe Wu |
| title |
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| title_short |
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| title_full |
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| title_fullStr |
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| title_full_unstemmed |
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype |
| title_sort |
glioblastoma epigenome profiling identifies sox10 as a master regulator of molecular tumour subtype |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/50c3ca33473a428aa36c9a52cf6638ef |
| work_keys_str_mv |
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