Defining Microbiome Health through a Host Lens

ABSTRACT We are walking ecosystems, inoculated at birth with a unique set of microbes that are integral to the functioning of our bodies. The physiology of our commensal microbiota is intertwined with our metabolism, immune function, and mental state. The specifics of this entanglement remain largel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Sean M. Gibbons
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	ecology evolution health host response microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/50da03d6cacb4edba56028655efb5323
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:50da03d6cacb4edba56028655efb5323
record_format	dspace
spelling	oai:doaj.org-article:50da03d6cacb4edba56028655efb53232021-12-02T19:46:18ZDefining Microbiome Health through a Host Lens10.1128/mSystems.00155-192379-5077https://doaj.org/article/50da03d6cacb4edba56028655efb53232019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00155-19https://doaj.org/toc/2379-5077ABSTRACT We are walking ecosystems, inoculated at birth with a unique set of microbes that are integral to the functioning of our bodies. The physiology of our commensal microbiota is intertwined with our metabolism, immune function, and mental state. The specifics of this entanglement remain largely unknown and are somewhat unique to individuals, and when any one piece of this complex system breaks, our health can suffer. There appear to be many ways to build a healthy, functional microbiome and several distinct ways in which it can break. Despite the hundreds of associations with human disease, there are only a handful of cases where the exact contribution of the microbiome to the etiology of disease is known. Our laboratory takes a systems approach, integrating dynamic high-throughput host phenotyping with eco-evolutionary dynamics and metabolism of gut microbiota to better define health and disease for each individual at the ecosystem level.Sean M. GibbonsAmerican Society for Microbiologyarticleecologyevolutionhealthhost responsemicrobiomeMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ecology evolution health host response microbiome Microbiology QR1-502
spellingShingle	ecology evolution health host response microbiome Microbiology QR1-502 Sean M. Gibbons Defining Microbiome Health through a Host Lens
description	ABSTRACT We are walking ecosystems, inoculated at birth with a unique set of microbes that are integral to the functioning of our bodies. The physiology of our commensal microbiota is intertwined with our metabolism, immune function, and mental state. The specifics of this entanglement remain largely unknown and are somewhat unique to individuals, and when any one piece of this complex system breaks, our health can suffer. There appear to be many ways to build a healthy, functional microbiome and several distinct ways in which it can break. Despite the hundreds of associations with human disease, there are only a handful of cases where the exact contribution of the microbiome to the etiology of disease is known. Our laboratory takes a systems approach, integrating dynamic high-throughput host phenotyping with eco-evolutionary dynamics and metabolism of gut microbiota to better define health and disease for each individual at the ecosystem level.
format	article
author	Sean M. Gibbons
author_facet	Sean M. Gibbons
author_sort	Sean M. Gibbons
title	Defining Microbiome Health through a Host Lens
title_short	Defining Microbiome Health through a Host Lens
title_full	Defining Microbiome Health through a Host Lens
title_fullStr	Defining Microbiome Health through a Host Lens
title_full_unstemmed	Defining Microbiome Health through a Host Lens
title_sort	defining microbiome health through a host lens
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/50da03d6cacb4edba56028655efb5323
work_keys_str_mv	AT seanmgibbons definingmicrobiomehealththroughahostlens
_version_	1718376025243516928

Defining Microbiome Health through a Host Lens

Ejemplares similares