The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from <named-content content-type="genus-species">Staphylococcus aureus</named-content>

The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT The innate immune system uses Toll-like receptor (TLR) 2 to detect conserved bacterial lipoproteins of invading pathogens. The lipid anchor attaches lipoproteins to the cytoplasmic membrane and prevents their release from the bacterial cell envelope. How bacteria release lipoproteins and ho...

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Bibliographic Details
Main Authors: Katja Schlatterer, Christian Beck, Dennis Hanzelmann, Marco Lebtig, Birgit Fehrenbacher, Martin Schaller, Patrick Ebner, Mulugeta Nega, Michael Otto, Dorothee Kretschmer, Andreas Peschel
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Staphylococcus aureus
leukocytes
lipoproteins
pore-forming toxins
Toll-like receptors
vesicles
Microbiology
QR1-502
Online Access:https://doaj.org/article/50db06f6b2f1472d8fdc42ff1add844b
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https://doaj.org/article/50db06f6b2f1472d8fdc42ff1add844b

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