The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

Summary: The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specifically recognizes linear ubiquitin chains, but its...

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Autores principales: Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Biological sciences
Molecular biology
Immune response
Science
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Acceso en línea:https://doaj.org/article/50f34cedbe9040a0b591ac5680f24ec3
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https://doaj.org/article/50f34cedbe9040a0b591ac5680f24ec3

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