Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer

ABSTRACT The first step in HIV-1 entry is the attachment of the envelope (Env) trimer to target cell CD4. As such, the CD4-binding site (CD4bs) remains one of the few universally accessible sites for antibodies (Abs). We recently described a method of isolating Abs directly from the circulating plas...

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Autores principales: William D. Tolbert, Dung N. Nguyen, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Marzena Pazgier
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
HIV
Acceso en línea:https://doaj.org/article/5104684864774f40bf9f29c19369a58c
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