Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer
ABSTRACT The first step in HIV-1 entry is the attachment of the envelope (Env) trimer to target cell CD4. As such, the CD4-binding site (CD4bs) remains one of the few universally accessible sites for antibodies (Abs). We recently described a method of isolating Abs directly from the circulating plas...
Guardado en:
Autores principales: | William D. Tolbert, Dung N. Nguyen, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Marzena Pazgier |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5104684864774f40bf9f29c19369a58c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Fixations of the HIV-1 env gene refute neutralism: New evidence for pan-selective evolution
por: Valenzuela,Carlos Y, et al.
Publicado: (2010) -
Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation
por: Christina Guzzo, et al.
Publicado: (2018) -
Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope
por: Brandyn R. West, et al.
Publicado: (2018) -
A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
por: Meredith E. Davis-Gardner, et al.
Publicado: (2020) -
Misconceptions and false expectations in neutral evolution
por: VALENZUELA,CARLOS Y.
Publicado: (2000)