RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma

RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma

<b>Background:</b> Malignant glioma (MG) is an aggressive malignant brain tumor. Despite advances in multidisciplinary treatment, overall survival rates remain low. A trifluoroethyl amide derivative of 2-cyano-3-,12-dioxoolean-1,9-dien-28-oic acid (CDDO), CDDO–trifluoroethyl amide (CDDO–...

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Bibliographic Details
Main Authors: Tai-Hsin Tsai, Ann-Shung Lieu, Tzuu-Yuan Huang, Aij-Lie Kwan, Chih-Lung Lin, Yi-Chiang Hsu
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
RTA404
malignant glioma
apoptosis
checkpoint kinase
Medicine
R
Online Access:https://doaj.org/article/511de4c9be2447bebdd9b447628e9820
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https://doaj.org/article/511de4c9be2447bebdd9b447628e9820

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