Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Several families of natural compounds target core components of the pre-mRNA splicing machinery and display anti-tumor activity. Here the authors show that particular sequence features can be linked to drug response, and that drugs with very similar chemical structures display substantially differen...

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Autores principales: Luisa Vigevani, André Gohr, Thomas Webb, Manuel Irimia, Juan Valcárcel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/51214b9023cc455398337408c0f8b445
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