Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Several families of natural compounds target core components of the pre-mRNA splicing machinery and display anti-tumor activity. Here the authors show that particular sequence features can be linked to drug response, and that drugs with very similar chemical structures display substantially differen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luisa Vigevani, André Gohr, Thomas Webb, Manuel Irimia, Juan Valcárcel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51214b9023cc455398337408c0f8b445
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:51214b9023cc455398337408c0f8b445
record_format	dspace
spelling	oai:doaj.org-article:51214b9023cc455398337408c0f8b4452021-12-02T17:01:16ZMolecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP10.1038/s41467-017-02007-z2041-1723https://doaj.org/article/51214b9023cc455398337408c0f8b4452017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02007-zhttps://doaj.org/toc/2041-1723Several families of natural compounds target core components of the pre-mRNA splicing machinery and display anti-tumor activity. Here the authors show that particular sequence features can be linked to drug response, and that drugs with very similar chemical structures display substantially different effects on splicing regulation.Luisa VigevaniAndré GohrThomas WebbManuel IrimiaJuan ValcárcelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luisa Vigevani André Gohr Thomas Webb Manuel Irimia Juan Valcárcel Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
description	Several families of natural compounds target core components of the pre-mRNA splicing machinery and display anti-tumor activity. Here the authors show that particular sequence features can be linked to drug response, and that drugs with very similar chemical structures display substantially different effects on splicing regulation.
format	article
author	Luisa Vigevani André Gohr Thomas Webb Manuel Irimia Juan Valcárcel
author_facet	Luisa Vigevani André Gohr Thomas Webb Manuel Irimia Juan Valcárcel
author_sort	Luisa Vigevani
title	Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
title_short	Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
title_full	Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
title_fullStr	Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
title_full_unstemmed	Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
title_sort	molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting u2 snrnp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/51214b9023cc455398337408c0f8b445
work_keys_str_mv	AT luisavigevani molecularbasisofdifferential3splicesitesensitivitytoantitumordrugstargetingu2snrnp AT andregohr molecularbasisofdifferential3splicesitesensitivitytoantitumordrugstargetingu2snrnp AT thomaswebb molecularbasisofdifferential3splicesitesensitivitytoantitumordrugstargetingu2snrnp AT manuelirimia molecularbasisofdifferential3splicesitesensitivitytoantitumordrugstargetingu2snrnp AT juanvalcarcel molecularbasisofdifferential3splicesitesensitivitytoantitumordrugstargetingu2snrnp
_version_	1718382206771003392

Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP

Ejemplares similares