MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Activation of interleukin-17 (IL-17) receptor signaling within intestinal epithelial cells (IECs) promotes colorectal cancer development. Here, the authors show that miR-146a limits inflammation-induced colorectal carcinogenesis by inhibiting both IL-17 induction from myeloid cells and inhibiting IL...

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Autores principales: Lucien P. Garo, Amrendra K. Ajay, Mai Fujiwara, Galina Gabriely, Radhika Raheja, Chantal Kuhn, Brendan Kenyon, Nathaniel Skillin, Ryoko Kadowaki-Saga, Shrishti Saxena, Gopal Murugaiyan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/51279124a70d4a388df327b36573d6f3
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spelling oai:doaj.org-article:51279124a70d4a388df327b36573d6f32021-12-02T13:39:33ZMicroRNA-146a limits tumorigenic inflammation in colorectal cancer10.1038/s41467-021-22641-y2041-1723https://doaj.org/article/51279124a70d4a388df327b36573d6f32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22641-yhttps://doaj.org/toc/2041-1723Activation of interleukin-17 (IL-17) receptor signaling within intestinal epithelial cells (IECs) promotes colorectal cancer development. Here, the authors show that miR-146a limits inflammation-induced colorectal carcinogenesis by inhibiting both IL-17 induction from myeloid cells and inhibiting IL-17R signaling within IECs.Lucien P. GaroAmrendra K. AjayMai FujiwaraGalina GabrielyRadhika RahejaChantal KuhnBrendan KenyonNathaniel SkillinRyoko Kadowaki-SagaShrishti SaxenaGopal MurugaiyanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lucien P. Garo
Amrendra K. Ajay
Mai Fujiwara
Galina Gabriely
Radhika Raheja
Chantal Kuhn
Brendan Kenyon
Nathaniel Skillin
Ryoko Kadowaki-Saga
Shrishti Saxena
Gopal Murugaiyan
MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
description Activation of interleukin-17 (IL-17) receptor signaling within intestinal epithelial cells (IECs) promotes colorectal cancer development. Here, the authors show that miR-146a limits inflammation-induced colorectal carcinogenesis by inhibiting both IL-17 induction from myeloid cells and inhibiting IL-17R signaling within IECs.
format article
author Lucien P. Garo
Amrendra K. Ajay
Mai Fujiwara
Galina Gabriely
Radhika Raheja
Chantal Kuhn
Brendan Kenyon
Nathaniel Skillin
Ryoko Kadowaki-Saga
Shrishti Saxena
Gopal Murugaiyan
author_facet Lucien P. Garo
Amrendra K. Ajay
Mai Fujiwara
Galina Gabriely
Radhika Raheja
Chantal Kuhn
Brendan Kenyon
Nathaniel Skillin
Ryoko Kadowaki-Saga
Shrishti Saxena
Gopal Murugaiyan
author_sort Lucien P. Garo
title MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
title_short MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
title_full MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
title_fullStr MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
title_full_unstemmed MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
title_sort microrna-146a limits tumorigenic inflammation in colorectal cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/51279124a70d4a388df327b36573d6f3
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AT amrendrakajay microrna146alimitstumorigenicinflammationincolorectalcancer
AT maifujiwara microrna146alimitstumorigenicinflammationincolorectalcancer
AT galinagabriely microrna146alimitstumorigenicinflammationincolorectalcancer
AT radhikaraheja microrna146alimitstumorigenicinflammationincolorectalcancer
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