Multistage hematopoietic stem cell regulation in the mouse: A combined biological and mathematical approach

Summary: We have reconciled steady-state and stress hematopoiesis in a single mathematical model based on murine in vivo experiments and with a focus on hematopoietic stem and progenitor cells. A phenylhydrazine stress was first applied to mice. A reduced cell number in each progenitor compartment w...

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Autores principales: Céline Bonnet, Panhong Gou, Simon Girel, Vincent Bansaye, Catherine Lacout, Karine Bailly, Marie-Hélène Schlagetter, Evelyne Lauret, Sylvie Méléard, Stéphane Giraudier
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/51509df1070a4d4585faa5eea2a5d7f2
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