Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined

Abstract A/H5N1 influenza viruses pose a threat to human and animal health. A fully avian A/H5N1 influenza virus was previously shown to acquire airborne transmissibility between ferrets upon accumulation of five or six substitutions that affected three traits: polymerase activity, hemagglutinin sta...

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Autores principales: Mathilde Richard, Sander Herfst, Judith M. A. van den Brand, Dennis de Meulder, Pascal Lexmond, Theo M. Bestebroer, Ron A. M. Fouchier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/517fb06f055b4f4cae1e52f7a0491796
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