A rotary mechanism for allostery in bacterial hybrid malic enzymes

Bacterial malic enzymes (ME) transform malate to pyruvate. One group, hybrid ME enzymes, are regulated by acetyl-CoA, linking the enzyme activity to the metabolic state of the cell. Structures of a representative hybrid ME MaeB reveal large conformational rearrangements that provide insight into the...

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Bibliographic Details
Main Authors: Christopher John Harding, Ian Thomas Cadby, Patrick Joseph Moynihan, Andrew Lee Lovering
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/5190409fbdc14f5b84ad4f155f6403ed
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