Autophagy regulates lipid metabolism through selective turnover of NCoR1

Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and...

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Autores principales:	Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon-Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51a6699afdbe409189590eaa1356ad95
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spelling	oai:doaj.org-article:51a6699afdbe409189590eaa1356ad952021-12-02T14:38:36ZAutophagy regulates lipid metabolism through selective turnover of NCoR110.1038/s41467-019-08829-32041-1723https://doaj.org/article/51a6699afdbe409189590eaa1356ad952019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08829-3https://doaj.org/toc/2041-1723Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.Tetsuya SaitoAkiko KumaYuki SugiuraYoshinobu IchimuraMiki ObataHiroshi KitamuraShujiro OkudaHyeon-Cheol LeeKazutaka IkedaYumi KanegaeIzumu SaitoJohan AuwerxHozumi MotohashiMakoto SuematsuTomoyoshi SogaTakehiko YokomizoSatoshi WaguriNoboru MizushimaMasaaki KomatsuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu Autophagy regulates lipid metabolism through selective turnover of NCoR1
description	Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.
format	article
author	Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu
author_facet	Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu
author_sort	Tetsuya Saito
title	Autophagy regulates lipid metabolism through selective turnover of NCoR1
title_short	Autophagy regulates lipid metabolism through selective turnover of NCoR1
title_full	Autophagy regulates lipid metabolism through selective turnover of NCoR1
title_fullStr	Autophagy regulates lipid metabolism through selective turnover of NCoR1
title_full_unstemmed	Autophagy regulates lipid metabolism through selective turnover of NCoR1
title_sort	autophagy regulates lipid metabolism through selective turnover of ncor1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/51a6699afdbe409189590eaa1356ad95
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Autophagy regulates lipid metabolism through selective turnover of NCoR1

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