Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas.
Microglia (brain resident macrophages) accumulate in malignant gliomas and instead of initiating the anti-tumor response, they switch to a pro-invasive phenotype, support tumor growth, invasion, angiogenesis and immunosuppression by release of cytokines/chemokines and extracellular matrix proteases....
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| Auteurs principaux: | , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2011
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| Accès en ligne: | https://doaj.org/article/51b303dc86ad4a7e9c6fdb31f3259d2e |
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