Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

The Ups/PRELI family mediates intramitochondrial lipid distribution and synthesis by shuttling phospholipids between both mitochondrial membranes. Here the authors combine X-ray crystallography, MD simulations and yeast genetic screens and identify residues that are important for Ups/PRELI lipid spe...

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Autores principales:	Xeni Miliara, Takashi Tatsuta, Jamie-Lee Berry, Sarah L. Rouse, Kübra Solak, Dror S. Chorev, Di Wu, Carol V. Robinson, Stephen Matthews, Thomas Langer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51be78de046c436f8df261a65888f530
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spelling	oai:doaj.org-article:51be78de046c436f8df261a65888f5302021-12-02T17:02:10ZStructural determinants of lipid specificity within Ups/PRELI lipid transfer proteins10.1038/s41467-019-09089-x2041-1723https://doaj.org/article/51be78de046c436f8df261a65888f5302019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09089-xhttps://doaj.org/toc/2041-1723The Ups/PRELI family mediates intramitochondrial lipid distribution and synthesis by shuttling phospholipids between both mitochondrial membranes. Here the authors combine X-ray crystallography, MD simulations and yeast genetic screens and identify residues that are important for Ups/PRELI lipid specificity and reveal a dual lipid recognition mechanism in Ups/PRELI family members.Xeni MiliaraTakashi TatsutaJamie-Lee BerrySarah L. RouseKübra SolakDror S. ChorevDi WuCarol V. RobinsonStephen MatthewsThomas LangerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xeni Miliara Takashi Tatsuta Jamie-Lee Berry Sarah L. Rouse Kübra Solak Dror S. Chorev Di Wu Carol V. Robinson Stephen Matthews Thomas Langer Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
description	The Ups/PRELI family mediates intramitochondrial lipid distribution and synthesis by shuttling phospholipids between both mitochondrial membranes. Here the authors combine X-ray crystallography, MD simulations and yeast genetic screens and identify residues that are important for Ups/PRELI lipid specificity and reveal a dual lipid recognition mechanism in Ups/PRELI family members.
format	article
author	Xeni Miliara Takashi Tatsuta Jamie-Lee Berry Sarah L. Rouse Kübra Solak Dror S. Chorev Di Wu Carol V. Robinson Stephen Matthews Thomas Langer
author_facet	Xeni Miliara Takashi Tatsuta Jamie-Lee Berry Sarah L. Rouse Kübra Solak Dror S. Chorev Di Wu Carol V. Robinson Stephen Matthews Thomas Langer
author_sort	Xeni Miliara
title	Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
title_short	Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
title_full	Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
title_fullStr	Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
title_full_unstemmed	Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
title_sort	structural determinants of lipid specificity within ups/preli lipid transfer proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/51be78de046c436f8df261a65888f530
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Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

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