Reprogramming signal transduction through a designer receptor tyrosine kinase

Kongkrongtong et al. present motif-based engineering of tyrosine kinase receptor for reprogramming signal transduction. Here, by swapping internal tyrosine of receptor with those that bind intracellular STAT signaling proteins, they demonstrate that specificity of this receptor can be reprogrammed w...

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Autores principales: Tatphon Kongkrongtong, Yuka Sumigama, Teruyuki Nagamune, Masahiro Kawahara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/51e7fc3119c54093bac348a9d980a008
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