Reprogramming signal transduction through a designer receptor tyrosine kinase

Kongkrongtong et al. present motif-based engineering of tyrosine kinase receptor for reprogramming signal transduction. Here, by swapping internal tyrosine of receptor with those that bind intracellular STAT signaling proteins, they demonstrate that specificity of this receptor can be reprogrammed w...

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Autores principales:	Tatphon Kongkrongtong, Yuka Sumigama, Teruyuki Nagamune, Masahiro Kawahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/51e7fc3119c54093bac348a9d980a008
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spelling	oai:doaj.org-article:51e7fc3119c54093bac348a9d980a0082021-12-02T16:04:30ZReprogramming signal transduction through a designer receptor tyrosine kinase10.1038/s42003-021-02287-82399-3642https://doaj.org/article/51e7fc3119c54093bac348a9d980a0082021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02287-8https://doaj.org/toc/2399-3642Kongkrongtong et al. present motif-based engineering of tyrosine kinase receptor for reprogramming signal transduction. Here, by swapping internal tyrosine of receptor with those that bind intracellular STAT signaling proteins, they demonstrate that specificity of this receptor can be reprogrammed with this approach.Tatphon KongkrongtongYuka SumigamaTeruyuki NagamuneMasahiro KawaharaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tatphon Kongkrongtong Yuka Sumigama Teruyuki Nagamune Masahiro Kawahara Reprogramming signal transduction through a designer receptor tyrosine kinase
description	Kongkrongtong et al. present motif-based engineering of tyrosine kinase receptor for reprogramming signal transduction. Here, by swapping internal tyrosine of receptor with those that bind intracellular STAT signaling proteins, they demonstrate that specificity of this receptor can be reprogrammed with this approach.
format	article
author	Tatphon Kongkrongtong Yuka Sumigama Teruyuki Nagamune Masahiro Kawahara
author_facet	Tatphon Kongkrongtong Yuka Sumigama Teruyuki Nagamune Masahiro Kawahara
author_sort	Tatphon Kongkrongtong
title	Reprogramming signal transduction through a designer receptor tyrosine kinase
title_short	Reprogramming signal transduction through a designer receptor tyrosine kinase
title_full	Reprogramming signal transduction through a designer receptor tyrosine kinase
title_fullStr	Reprogramming signal transduction through a designer receptor tyrosine kinase
title_full_unstemmed	Reprogramming signal transduction through a designer receptor tyrosine kinase
title_sort	reprogramming signal transduction through a designer receptor tyrosine kinase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/51e7fc3119c54093bac348a9d980a008
work_keys_str_mv	AT tatphonkongkrongtong reprogrammingsignaltransductionthroughadesignerreceptortyrosinekinase AT yukasumigama reprogrammingsignaltransductionthroughadesignerreceptortyrosinekinase AT teruyukinagamune reprogrammingsignaltransductionthroughadesignerreceptortyrosinekinase AT masahirokawahara reprogrammingsignaltransductionthroughadesignerreceptortyrosinekinase
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Reprogramming signal transduction through a designer receptor tyrosine kinase

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